METHYL CHLORODIFLUOROACETATE. A CONVENIENT TRIFLUOROMETHYLATING AGENT

DOI: 10.1016/0040-4039(91)80566-O

Source and publish data:

Tetrahedron Letters p. 7689 - 7690 (1991)

Update date:2022-08-16

Topics:

Authors:

Su, De-Bao

Duan, Jian-Xing

Chen, Quing-Yun

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Article abstract of DOI:10.1016/0040-4039(91)80566-O

Treatment of methyl chlorodifluoroacetate with organic halides in the presence of KF and CuI at 100-120 deg C for 7-8 h in DMF gave the corresponding trifluoromethylated derivatives in moderate to high yields.

Full text of DOI:10.1016/0040-4039(91)80566-O

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