Synthesis and biological activities of a novel class of azole-containing antifungal agents

DOI: 10.1016/0960-894X(96)00222-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1335 - 1338 (1996)

Update date:2022-08-10

Topics:

Authors:

Liu, Lee Tai

Lin, Ya-Chuan

Wang, Chia-Lin J.

Lin, Mei-Shey

Yen, Su-Chen

Chen, Hsiao-Jen

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Article abstract of DOI:10.1016/0960-894X(96)00222-3

A series of novel 1,2,3,4-tetrahydroisoquinoline derived azoles has been designed and synthesized as antifungal agents which might function as inhibitors of cytochrome P-450 dependent lanosterol 14α-demethylase. In vitro tests showed that some of these compounds, especially 5b and 6b, effectively inhibit the growth of several strains of yeasts as well as molds.

Full text of DOI:10.1016/0960-894X(96)00222-3

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