Synthesis of novel substituted pyridines as inhibitors of endothelin converting enzyme-1 (ECE-1)

Article abstract of DOI:10.1016/S0960-894X(98)00375-8

A series of bi-aryl pyridine carboxylic acids has been prepared and evaluated as inhibitors of ECE-1. The analogs were prepared by Pd catalyzed cross couplings of halogenated pyridines with heteroaryl organo -boranes, - tinate or -zincate derivatives.