Bioorganic and Medicinal Chemistry Letters p. 189 - 194 (1998)
Update date:2022-08-02
Topics:
Ojima, Iwao
Bounaud, Pierre-Yves
Takeuchi, Craig
Pera, Paula
Bernacki, Ralph J.
New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (≤99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.
View MoreWUXI KINGHAN BIO-MEDICAL&CHEMICAL INC.
Contact:13861062998
Address:Room 1316,No.1619 Huishan Avenue,Wuxi,China
Shenyang Mole pharmaceutical Technology Development Co.,Ltd
Contact:+86-24-31204918/13889278616
Address:No.44, wanliutang road, shenhe District of Shenyang
shanghai jinshan pharmaceutical Co.,Ltd
Contact:021-57363011,13681638167
Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
ShangHai Ruiyi Medical Technology Co.,Ltd.
Contact:+86-21-54718086
Address:No951 Jianchuan RD,Minhang District
Jiangsu Dacheng Pharmaceutical and Chemical Co.,Ltd
Contact:+86-0517-87036900
Address:Chuzhou Chemical park, Huai'an, Jiangsu Province
Doi:10.1016/j.tet.2021.132387
(2021)Doi:10.1039/c3ob42341g
(2014)Doi:10.1021/jo01267a010
(1968)Doi:10.1016/j.tet.2015.05.115
(2015)Doi:10.1021/jm00052a010
(1994)Doi:10.1039/d1ob00942g
(2021)