Bioorganic and Medicinal Chemistry Letters p. 189 - 194 (1998)
Update date:2022-08-02
Topics:
Ojima, Iwao
Bounaud, Pierre-Yves
Takeuchi, Craig
Pera, Paula
Bernacki, Ralph J.
New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (≤99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.
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