Total synthesis of (-)-mniopetal E, a novel biologically intriguing drimane sesquiterpenoid

Article abstract of DOI:10.1016/S0040-4039(99)01631-7

Total synthesis of (-)-mniopetal E, the common skeleton of the biologically intriguing mniopetals A-D, was accomplished for the first time. The key step of the total synthesis was stereoselective intramolecular Diels-Alder reaction for construction of the octahydronaphthalene core structure. Our total synthesis as natural enantiomeric form established the unsettled absolute stereochemistry of the antibiotic.