A convenient preparation of protected 3′-deoxyguanosine from guanosine

Article abstract of DOI:10.1016/0040-4039(95)01447-P

Protected 3′-deoxyguanosine was synthesized from guanosine in five steps and 50% overall yield through reaction of the 2′,3′-diol with a-acetoxyisobutyryl bromide followed by base treatment to form 2′,3′-anhydroguanosine and subsequent selective reduction of the epoxide with LiHBEt₃.