Formation Of (N-Heteroaryl)heteroarylmethanamines From Heteroaromatic Aldehydes And Heteroaromatic Amines

Article abstract of DOI:10.3987/COM-93-S109

The reactions of heteroaromatic aldehydes with heteroaromatic amines show significant differences depending on the heteroaromatic moieties present both in the aldehydes and in the amines, giving imines (3) or arenes (5).The direct formation of (N-heteroaryl)heteroarylmethanamines (4) is achieved by the Leuckart-Wallach reaction.Reaction conditions for the formation of amines (4) by NaBH4 reduction of imines (3) are also reported.