SYNTHESIS OF NEW α-CHLOROACRYL-AMIDES, THIOAMIDES AND AMIDINES FROM SATURATED AMIDES.

Article abstract of DOI:10.1016/S0040-4020(01)96684-0

Chlorination of saturated amide chlorides followed by hydrolysis, thiolysis, aminolysis and catalysed dehydrochlorination leads to α-chloro acrylamide derivatives in high yield.The reaction sequence is applied to lactames and can also be extended to the synthesis of α-chloro acrylthioamide and amidine.