Synthesis of F-alkyl α-hydroxy acids and esters from F-alkyl epoxides and F-alkyl α-bromo acids and esters from F-alkyl bromohydrins

Article abstract of DOI:10.1016/S0022-1139(97)00051-1

F-alkyl α-hydroxy acids and F-alkyl α-bromo acids were prepared respectively by the nitric acid ring-opening oxidative reaction of F-alkyl oxiranes, and oxidation by chromic acid of F-alkyl bromohydrins. The synthesized acids were converted to the corresponding methyl esters which may prove to be useful in the synthesis of F-alkylated heterocycles.