Novel one-pot cyclization of ortho substituted benzonitriles to 3-amino-1,2-benzisoxazoles

Article abstract of DOI:10.1016/0040-4039(96)00425-X

A novel one-pot synthesis of 3-amino-1,2-benzisoxazoles (iii), from ortho substituted benzonitriles (i), is described. The synthesis likely involves a SNAr reaction of an activated ortho halo or nitro group by a hydroxamate anion, followed by an intra-mol