Bioorganic and Medicinal Chemistry Letters p. 1769 - 1772 (1997)
Update date:2022-08-11
Topics:
Finlay, Heather J.
Honda, Tadashi
Gribble, Gordon W.
Danielpour, David
Benoit, Nicole E.
Suh, Nanjoo
Williams, Charlotte
Sporn, Michael B.
Syntheses of eight novel A-ring cleaved oleanane and ursane analogs are described. These compounds were assessed for their ability to inhibit cell proliferation in NRP. 152 prostate cells. Four A-ring cleaved derivatives showed significant activity; 5β-(1-methyl-2-ethyl)-10α-(3-aminopropyl)- des-A-urs-12-en-28-oic acid was the most active compound, (IC50, 0.3 μM).
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Doi:10.1246/bcsj.65.831
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