Bioorganic and Medicinal Chemistry Letters p. 1255 - 1260 (1997)
Update date:2022-08-17
Topics:
Hewawasam, Piyasena
Meanwell, Nicholas A.
Gribkoff, Valentin K.
Dworetzky, Steven I.
Boissard, Christopher G.
3-Aryl-3-hydroxyindol-2-ones have been identified as a novel class of BK channel openers. Synthesis of both racemic and chiral 3-aryl-3-hydroxyindolones is described along with their electrophysiological evaluation as activators of the cloned BK channel m
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