Bioorganic and Medicinal Chemistry Letters p. 3243 - 3248 (1999)
Update date:2022-08-11
Topics:
Van Niel, Monique B.
Beer, Margaret S.
Castro, Jose L.
Cheng, Susan K.F.
Evans, David C.
Heald, Anne
Hitzel, Laure
Hunt, Peter
Mortishire-Smith, Russell
O'Connor, Desmond
Watt, Alan P.
MacLeod, Angus M.
A solution phase synthesis for the preparation of 3-aryloxy-2-propanolamine libraries has been developed. This resulted in the identification of 5 as a ligand with dual affinity for 5-HT(1A) and serotonin re-uptake receptors which shows excellent pharmacokinetic parameters.
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Doi:10.1007/BF00810067
(1986)Doi:10.1016/S0040-4039(00)99462-0
(1989)Doi:10.1039/c7md00173h
(2017)Doi:10.1016/j.ica.2019.05.014
(2019)Doi:10.1006/bioo.2000.1162
(2000)Doi:10.1135/cccc19932867
(1993)
