Polymethylenedioxy bis(2-hydroxyiminomethylpyridinium) as in vitro reactivators of organophosphorous inhibited eel acetylcholinesterase

Article abstract of DOI:10.1016/0223-5234(88)90168-7

The synthesis and in vitro AChE reactivating potency of 5 new bridged pyridinium-2 carbaldoximes are described.Tested as reactivators and protectors in vitro against 5 organophosphorous inhibitors, they show a particularly interesting activity against paraoxon and tabun.These oximes themselves are reversible AChE inhibitors.Keywords - acetylcholinesterase reactivators; organophosphorous poisons; bridged pyridinium oximes.