Absolute Configuration of Curacin A, a Novel Antimitotic Agent from the Tropical Marine Cyanobacterium Lyngbya majuscula

Article abstract of DOI:10.1016/0040-4039(95)00030-G

Curacin A is a structurally novel antimitotic agent isolated from the Caribbean cyanobacterium Lyngbya majuscula.Its planar structure has been previously determined from a spectroscopic investigation, Here, we define the complete relative and absolute configuration of curacin A by comparison of products obtained from chemical degradation of the natural product with the same substances prepared by synthesis.Curacin A is shown to have 2R, 13R, 19R, 21S absolute configuration.