Journal of Medicinal Chemistry p. 1057 - 1060 (1974)
Update date:2022-08-17
Topics:
Chan
Robinson
The preparation and absolute configuration of the stereoisomeric forms of lactoyl β methylcholine iodide with the 2 racemic forms of the molecule are reported. None of the stereoisomers were substrates for the enzyme acetylcholinesterase, whereas two stereoisomers (L lactoyl β methylcholine and D lactoyl L β methylcholine iodide) were poor substrates for cholinesterase. Results are analyzed in the light of previous studies of the chiral requirements of these 2 enzymes and an attempt is made to define the rate limiting or prohibited step in the enzyme catalyzed reaction with these compounds.
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Doi:10.1021/ja039551q
(2004)Doi:10.1016/j.jssc.2008.08.019
(2008)Doi:10.1016/j.ejmech.2014.12.013
(2015)Doi:10.1007/s10895-013-1258-y
(2013)Doi:10.1021/ja00543a025
(1980)Doi:10.1016/S0008-6215(00)81092-7
(1969)
