Enantioselective Transesterifications of 2-Methyl-1-alcohols Catalysed by Lipases from Pseudomonas

Article abstract of DOI:10.1016/S0957-4166(00)86227-8

Racemic β-methyl-2-thiophenepropanol was resolved (E = 200) via transesterification catalysed by lipase from Pseudomonas fluorescens using an excess of vinyl acetate in chloroform at an initial water activity: a_w = 0.32.When trying to resolve rac-2-methyl-1-alkanols more modest E-values were obtained (E = 10) and were of the same order of magnitude irrespective of substrate chainlength, water activity, immobilization, acyl donor or other Pseudomonas derived lipases.However, the reaction rates are affected by variations of these parameters.Both the rates and E-values were influenced by the nature of the solvent.