
Journal of Organic Chemistry p. 3717 - 3722 (1995)
Update date:2022-08-11
Topics:
Wityak, John
Earl, Richard A.
Abelman, Matthew M.
Bethel, Yvonne B.
Fisher, Barbara N.
et al.
The asymmetric synthesis of thrombin inhibitor DuP 714 (1) is described.The route uses the Matteson boronic ester homologation to prepare the key intermediate, α-aminoboronic acid 4.New methodology was developed for the formamidination of boroornithine peptides and for pinanediol boronate ester cleavage.
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