Journal of Pharmaceutical Sciences p. 1531 - 1535 (1984)
Update date:2022-08-17
Topics:
Scott
Alt
Kemp
Hayes
Telang
A series of methyl-substituted 1,2,3,4-tetrahydrocarbazoles was synthesized and screened for in vitro activity against tyrosine hydroxylase and dopamine-β-hydroxylase. The most potent compounds were evaluated for inhibition of norepinephrine biosynthesis in rats. The results indicated no significant decrease in norepinephrine levels at three dosage levels.
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