Synthesis and stability of [1,3-14C2]-glyceryl trinitrate

Article abstract of DOI:10.1002/jlcr.2580341115

The synthesis of [1,3-¹⁴C₂]-glyceryl trinitrate ([¹⁴C]-GTN) labelled with quasi carrier free carbon-14 atom in the 1,3-positions of the molecule was effected in four reaction steps from ¹⁴CO₂ ( 3,5% overall yield). The chemical and radiochemical purity of [¹⁴C]-GTN was found better than 99% controlled by HPLC-Radioactivity Monitor and TLC-Digital Autoradiograph methods. Study of the radiochemical stability in dilute solution at 5 °C shows l:hat the product can be stored at least for a month without detectable decomposition.