Macrolide biosynthesis: A single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae

DOI: 10.1016/S0960-894X(98)00553-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3117 - 3120 (1998)

Update date:2022-08-29

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Authors:

Graziani, Edmund I.

Cane, David E.

Betlach, Melanie C.

Kealey, James T.

McDaniel, Robert

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Article abstract of DOI:10.1016/S0960-894X(98)00553-8

The final step in the biosynthesis of methymycin, neomethymycin, and picromycin is an hydroxylation, shown to be carded out by the cytochrome P- 450 monooxygenase, PicK. Direct comparison of the relative k(cat)/K(m) values for the two substrates, YC-17 and narbomycin, showed a threefold rate preference of pick for narbomycin.

Full text of DOI:10.1016/S0960-894X(98)00553-8

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