A. Hawkins et al. / Tetrahedron Letters 54 (2013) 365–369
369
the b-carboline moiety, critical for biological activity, and therefore
could lend itself readily to analogue preparation of manzamine A
precursors through modification of the (hetero)aryl group. This
suitably functionalised advanced key intermediate could lead to
manzamine A in only a handful of steps and studies are ongoing
in our laboratories to realise this.
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Acknowledgements
We thank the EPSRC (Leadership Fellowship to D.J.D., student-
ship to A.H. and post-doctoral fellowship to P.J.) and GlaxoSmithK-
line (studentship to A.H.). We also thank Dr. Barbara Odell
(
University of Oxford) for NMR studies.
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