Synthetic Communications p. 3529 - 3533 (2004)
Update date:2022-08-16
Topics:
Sheng, Rong
Hu, Yongzhou
A novel and efficient method was developed to synthesize N-benzyl-4-formyl-piperidine, a key intermediate of Donepezil (Aricept). N-Benzyl-4-piperidone was reacted with dimethyloxosulfonium methylide to get epoxide, followed by rearrangement in the presence of magnesium bromide etherate to give target compound in high yield.
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