Computer aided benzothiazole derivatives. Synthesis, structure and biological study of new push-pull conjugated benzothiazolium salts

Article abstract of DOI:10.1515/HC.2001.7.4.331

As the conjugation is assumed to enhance the biological activity of push-pull type benzothiazolium salts, new compounds with extended conjugated bridge between benzothiazolium and phenyl ring were designed and synthesized. The compounds have been tested against the model microorganism Euglena gracilis as well as 6 microorganisms including Gram-positive and Gram-negative bacteria , a yeast and a mould. In accordance with predictions, the prepared compounds showed enhanced activity against Euglena and Gram-positive bacteria and some of them also interesting fungicidal and fungistatic activity.

Full text of DOI:10.1515/HC.2001.7.4.331

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