Application of the Pictet-Spengler reaction in combinatorial chemistry

Article abstract of DOI:10.1016/0040-4039(96)01219-1

Reaction of polymer bound tryptophan with a variety of aldehydes and ketones under Pictet-Spengler like conditions was found to produce 1,2,3,4-tetrahydro-β-carbolines in excellent yield. The straightforward, easily automated chemistry and the availability of numerous commercial aldehydes and ketones makes this approach ideal for combinatorial chemistry application.