Synthesis of Bilin-1,19-diones and Biladiene-ac-1,19-diones with C(10) Adamantyl and tert-Butyl Groups

Article abstract of DOI:10.1002/jhet.5570350404

Bilirubin and biliverdin analogs bearing bulky adamantyl and tert-butyl groups at the central C(10) position were synthesized and their structures were analyzed by nmr and ultraviolet-visible spectroscopy and by molecular mechanics calculations, all of which collectively indicated a preference for helical conformations.