An optimized synthesis of 2-methoxyestradiol, a naturally occurring human metabolite with anticancer activity

Article abstract of DOI:10.1080/00397919808004478

2-Methoxyestradiol, a naturally occurring human metabolite with demonstrated anticancer activity, has been synthesized in three steps and 76% yield from the bis(MOM) ether of 2-formylestradiol.

Full text of DOI:10.1080/00397919808004478

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Synthetic Communications:
An International Journal
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Synthetic Organic Chemistry
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An Optimized Synthesis
of 2-Methoxyestradiol, A
Naturally Occurring Human
Metabolite with Anticancer
Activity
Zhiqiang Wang a & Mark Cushman a
a Department of Medicinal Chemistry and
Molecular Pharmacology , School of Pharmacy
and Pharmacal Sciences, Purdue University ,
West Lafayette, 47907, Indiana
Published online: 23 Aug 2006.
To cite this article: Zhiqiang Wang & Mark Cushman (1998) An Optimized
Synthesis of 2-Methoxyestradiol, A Naturally Occurring Human Metabolite with
Anticancer Activity, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 28:23, 4431-4437, DOI:
10.1080/00397919808004478
To link to this article: http://dx.doi.org/10.1080/00397919808004478
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