Molecularly imprinted uniform-sized polymer-based stationary phase for naproxen

Article abstract of DOI:10.1246/cl.1997.555

A molecularly imprinted uniform-sized polymer-based stationary phase for (S)-naproxen has been prepared using 4-vinylpyridine and ethylenedimethacrylate as a host functional monomer and cross-linker, respectively. The imprinted polymer material could separate naproxen enantiomers with separation factor of 1.74. Further, the materials showed high selectivity for naproxen and moderate selectivity for other 2-arylpropionic acid derivatives. On the other hand, the imprinted polymer material showed little selectivity for other acidic, basic and neutral compounds.