Monatshefte fur Chemie p. 865 - 870 (1987)
Update date:2022-08-11
Topics:
Haeusler, Johannes
The oxidative decarboxylation sequence (1a --> 2a --> 3a --> 4a --> 5a) affording γ-aminobutanoic acid (5a) is adapted to the synthesis of its hydroxy derivative 5b.A facile high yield conversion of (2S,4R)-4-hydroxyproline-methylester-hydrochloride (7) to (R)-GABOB (5b) on a preparative scale is reported with the hydroxypyrrolidone 8 as the intermediate. - Keywords: Oxidation of amino acid derivatives; γ-Amino-β-hydroxybutanoic acid (GABOB); 1-Pyrroline-2-carboxylic acid derivatives
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