Journal of Medicinal Chemistry p. 1261 - 1264 (1980)
Update date:2022-08-30
Topics:
Grosso, John A.
Nichols, David E.
Nichols, Maxine B.
Yim, George K. W.
Based on the known biological activity of a variety of guanidine-containing agents, several N-substituted 3,4-dihydroquinazolines were synthesized.These compounds can be considered to be rigid analogues of phenylguanidines.In anesthetized rats the compounds decreased blood pressure and were antagonist of the pressor response to norepinephrine.
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