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Studies on preparation and characterization of novel MRI contrast agents for targeting organs and blood vessels

DOI: 10.1515/HC.2007.13.2-3.101

Source and publish data:

Heterocyclic Communications p. 101 - 108 (2007)

Update date:2022-08-17

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Authors:

Yu, GangYu, Gang

Yamashita, MitsujiYamashita, Mitsuji

Aoshima, KengoAoshima, Kengo

Kobayashi, MasatsuguKobayashi, Masatsugu

Kato, TatsunoriKato, Tatsunori

Kamikage, NaoKamikage, Nao

Takahashi, MasakiTakahashi, Masaki

Takayanagi, HisaoTakayanagi, Hisao

Oshikawa, TatsuoOshikawa, Tatsuo

Laurent, SofieLaurent, Sofie

Burtea, CarmenBurtea, Carmen

Vander ElstVander Elst

Muller, Robert N.Muller, Robert N.

Takehara, YasuoTakehara, Yasuo

Sakahara, HarumiSakahara, Harumi

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Article abstract of DOI:10.1515/HC.2007.13.2-3.101

To improve the poor properties of currently clinically used MRI contrast agent of Gd-DTPA (Gadolinium-Diethylenetriamine-N,N,N',N",N"- pentaacetic acid) complex, sugar dendritic derivatives which contains Gd-DTPA as the core part and four or twelve sugars as the terminal part, dendrimer 8(Gd-DTPA-D1Glc(OAc)) or dendrimer 10(Gd-DTPA-D2Glc(OAc)), respectively, were prepared. From the result of relaxivity profile of these Gd complexes depending on temperature and magnitude of magnetic field, the smaller size MRI contrast agent of Gd-DTPA, 8(Gd-DTPA-D1Glc(OAc)), showed similar behavior to that of Gd-DTPA and the dendrimer constructs DDS of Gd-DTPA and was proven to have the improved properties for MR imaging of blood vessel (MRA) as well as for targeting specific organs.

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Full text of DOI:10.1515/HC.2007.13.2-3.101

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