SEX DIFFERENCES OF ASA HYDROLYSIS IN RAT TISSUES
351
12. J . G. Spenney, Acetylsalicylic acid hydrolase of gastric
m ucosa. Am . J . Physiol. 234, E606–610 (1978).
13. J . G. Spenney and R. M. Nowell, Acetylsalicylate hydrolase
of rabbit gastric m ucosa. Isolation and purification. Drug
Metab. Dispos. 7, 215–219 (1979).
14. R. Mentlein, S. Heiland and E. Heym ann, Sim ultaneous
purification and com parative characterization of six serine
hydrolases from rat liver m icrosom es. Arch. Biochem .
Biophys. 200, 547–559 (1980).
15. K. N. White and D. B. Hope, Identification of aspirinase
with one of the carboxylesterases requiring a thiol group.
Biochem . J . 197, 771–773 (1981).
changes in hepatic m icrosom al carboxylesterases in rat.
Res. Com m un. Chem . Pathol. Pharm acol. 46, 245–258
(1984).
28. M. Hosokawa, T. Maki and T. Satoh, Multiplicity and regu-
lation of hepatic m icrosom al carboxylesterases in rats.
Mol. Pharm acol. 31, 579–584 (1987).
29. M. Hosokawa, T. Maki and T. Satoh, Differences in the
induction of carboxylesterase isoenzym es in rat liver
m icrosom es by xenobiotics. Biochem . Pharm acol. 37,
2708–2711 (1988).
30. S. A. Kam ath, F. A. Kim m erow and K. A. Narayan, A
sim ple procedure for the isolation of rat liver m icrosom es.
FEBS Lett. 17, 90–92 (1971).
31. J . G. Spenney, An ultraviolet absorbance m ethod for
determ ining acetylsalicylic acid hydrolase activity. Anal.
Biochem . 80, 578–584 (1977).
16. B. Ali and S. Kaur, Mam m alian tissue acetylsalicylic acid
esterase(s): identification, distribution and discrim ination
from other esterases. J . Pharm acol. Exp. Ther. 226, 589–
594 (1983).
17. E. Heym ann and W. J unge, Characterization of the iso-
enzym es of pig liver carboxylesterase. I. Chem ical studies.
Eur. J . Biochem . 95, 509–518 (1979).
18. E. Heym ann, Carboxylesterases and Am idases, In Enzy-
m atic Basis of Detoxication, Vol. II, ed. by W. B. J acoby,
pp. 291–323. Academ ic Press, New York (1980).
19. K. N. White and D. B. Hope, Partial purification and charac-
terization of a m icrosom al carboxylesterase specific for
salicylate esters from guinea-pig liver. Biochim . Biophys.
Acta 785, 138–147 (1984).
20. T. Tsujita, T. Miyada and H. Okuda, Purification of rat
kidney carboxylesterase and its com parison with other
tissue esterases. J . Biochem . (Tokyo) 103, 327–331 (1988).
21. M. Inoue, M. Morikawa, M. Tsuboi and M. Sugiura, Spec-
ies difference and characterization of intestinal esterase
on the hydrolizing activity of ester-type drugs. J pn. J .
Pharm acol. 29, 9–16 (1979).
22. R. Mentlein, M. Suttorp and E. Heym ann, Specificity of
purified m onoacylglycerol lipase, palm itoyl-CoA hydrolase,
and non-specific carboxylesterase from rat liver m icro-
som es. Arch. Biochem . Biophys. 228, 230–246 (1984).
23. M. R. Buchanan, J . A. Rischeke, R. Butt, A. G. G. Turpie,
J . Hirsh and J . Rosenfeld, The sex related differences
in aspirin pharm acokinetics in rabbits and m an and its
relationship to antiplatelet effects. Throm b. Res. 29, 125–
139 (1983).
32. O. H. Lowry, N. J . Rosenbrough, A. L. Farr and R. J .
Randall, Protein m easurem ents with the Folin phenol
reagent. J . Biol. Chem . 193, 265–275 (1951).
33. M.-Q. Su, F. K. Kinoshita, J . P. Frawley and K. P. DuBois,
Com parative inhibition of aliesterases and cholinesterase
in rats fed eighteen organophosphorus insecticides. Toxi-
col. Appl. Pharm acol. 20, 241–249 (1971).
34. L. Martinez Tabche and F. A. Posadas del Rio, Effects of
subchronic parathion adm inistration on sodium salicylate
excretion kinetics in fem ale rats. J . Appl. Toxicol. 9, 5–
8 (1989).
35. F. J aram illo-J uarez, F. A. Posadas del Rio, J . L. Reyes, M.
L. Rodriguez, E. I. Shanchez and L. H. Cuellar, Effects of
intrauterine exposure in parathion on the activity of renal
ATPases in offspring. J . Appl. Toxicol. 9, 401–405 (1989).
36. M. Inoue, M. Morikawa, M. Tsuboi, T. Yam ada and M.
Sugiura, Hydrolysis of ester-type drugs by the purified
esterase from hum an intestinal m ucosa. J pn. J . Pharm a-
col. 29, 17–25 (1979).
37. M. Inoue, M. Morikawa, M. Tsuboi, Y. Ito and M. Sugiura,
Com parative study of hum an intestinal and hepatic ester-
ases as related to enzym atic properties and hydrolizing
activity for ester-type drugs. J pn. J . Pharm acol. 30, 529–
535 (1980).
38. J . -A. Gustafsson, A. Mode, G. Norstedt and P. Skett, Sex
steroid induced changes in hepatic enzym es. Ann. Rev.
Physiol. 45, 51–60 (1983).
39. L. Staffas, L. Mankowitz, M. Soderstrom , A. Blanck, Y.
Porsch-Hallstrom , C. Sundberg, B. Mannervik, B. Olin, J .
Rydstrom and J . W. DePierre, Further characterization of
horm onal regulation of glutathione transferase in rat liver
and adrenal glands. Biochem . J . 286, 65–72 (1992).
40. T. Satoh, Role of carboxylesterases in xenobiotic m etab-
olism . Rev. Biochem . Toxicol. 8, 155–181 (1987).
41. R. Tallarida and R. Murray, Manual of Pharm acology Cal-
culations with Com puter Program s. Springer-Verlag, New
York (1981).
24. W. S. Schwark and D. J . Ecobichon, Characterization of
rat liver and kidney esterases. Can. J . Biochem . 45, 451–
455 (1967).
25. M. Raftell and K. Berzins, Sex differences in the pattern
of esterase-active antigens in m icrosom es from various
rat strains. Biochim . Biophys. Acta 499, 24–27 (1977).
26. M. Robbi and H. Beaufay, Purification and characterization
of various esterases from rat liver. Eur. J . Biochem . 137,
293–301 (1983).
27. M. Hosokawa, T. Satoh, S. Ohkawara, S. Ohm ori, T. Igara-
shi, K. Ueno and H. Kitagawa, Gonadal horm one-induced
1997 John Wiley & Sons, Ltd.
J. Appl. Toxicol., Vol. 17(6) 347–351 (1997)