A NOVEL SYNTHESIS OF (E)-3,7-DIMETHYL-2-OCTENE-1,8-DIOL SECRETED BY THE AFRICAN MONARCH USING THE RING-OPENING REACTION OF α-METHYL-β-PROPIOLACTONE

Article abstract of DOI:10.1016/S0040-4039(00)88593-7

The regioselective ring-opening reaction of α-methyl-β-propiolactone with 3,3-ethylenedioxybutylmagnesium bromide in the presence of copper(I) catalyst afforded 2-methyl-6-oxoheptanoic acid, which was easily converted into (E)-3,7-dimethyl-2-octene-1,8-diol in good yield.