Tetrahedron Letters p. 4693 - 4696 (1997)
Update date:2022-08-17
Topics:
Fernandez-Lafuente, Roberto
Guisan, Jose M.
Pregnolato, Massimo
Terreni, Marco
A new chemoenzymatic synthesis of Cefazolin through the correct assembly of three biotransformations catalyscd by D-aminoacid oxidase, glutaryl acylase and penicillin G acylase is described. This multienzymatic synthesis has been performed from the natural Cephalosporin C in fully aqueous medium without intermediate purification stages. Almost quantitative yields have been achieved in all the enzymatic reactions.
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(1945)
