Enantioselective carboxylation of α-methoxybenzyllithium generated via asymmetric lithiation with a t-BuLi/chiral bis(oxazoline) complex

DOI: 10.1016/S0040-4039(99)01364-7

Source and publish data:

Tetrahedron Letters p. 6809 - 6812 (1999)

Update date:2022-08-12

Topics:

Authors:

Komine, Nobuyuki

Wang, Lan-Fang

Tomooka, Katsuhiko

Nakai, Takeshi

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Article abstract of DOI:10.1016/S0040-4039(99)01364-7

Treatment of benzyl methyl ether with a t-BuLi/chiral bis(oxazoline) complex followed by carboxylation is shown to afford α-methoxy phenylacetic acid in high % ee (up to 95%). The asymmetric induction was proved to occur at the post-lithiation step.

Full text of DOI:10.1016/S0040-4039(99)01364-7

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