Journal of the Chemical Society - Faraday Transactions p. 2811 - 2820 (1991)
Update date:2022-08-11
Topics:
Crotti, Corrado
Cenini, Sergio
Todeschini, Roberto
Tollari, Stefano
A chemometric optimization of the Ru3(CO)12 catalysed deoxygenation of 2-nitrostilbene to 2-phenylindole was carried out.The effects of temperature, CO pressure, amounts of catalyst and substrate on conversion and selectivity were examined by factorial design/response surface methods.The conversion was found to increase on increasing the temperature and decreasing the CO pressure, it assumed a minimum value for medium amounts of catalyst and was almost independent of the amount of substrate.These results were also confirmed using a learning system and were used to develop a mechanism for the reaction.The data suggest two different mechanisms: one based on a Ru(CO)5 catalysed process and another one based on a Ru3(CO)12 catalysed process, which are first and zero order with respect to the substrate, respectively.
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