Enhancement of ricin toxin A chain immunotoxin activity: Synthesis, ionophoretic ability, and in vitro activity of monensin derivatives

Article abstract of DOI:10.1016/0006-2952(96)00176-1

Site-selective toxin delivery was achieved by coupling monoclonal antibody to the A chain subunit of ricin (RTA-IT). The cell-killing potency of RTA-IT can be drastically increased in vitro by using ionophores such as monensin. To reduce the intrinsic tox