Tandem radical nitrile transfer-cyclization reactions of 1,3- dioxane-4-nitriles: Synthesis of spirocyclic systems

Article abstract of DOI:10.1016/S0040-4020(97)01030-2

Reduction of remote halogen substituents with n-Bu₃SnH leads to efficient 1,4- and 1,5-nitrile transfer from 1,3-dioxane-4-nitriles and subsequent stereoselective reduction. These radical-transfer reactions provide a mild alternative to the Li/