Synthesis of hydrazides through an enzymatic hydrazinolysis reaction

Article abstract of DOI:10.1055/s-1991-26462

Amano PS lipase catalyzes the reaction of formic hydrazide, acetic hydrazide and methyl carbazate with various esters: α,β-unsaturated hydrazides were obtained by using methyl acrylate or vinyl crotonate. The reaction with ethyl (±)-2-chloropropionate yields the corresponding hydrazide in good yield but with moderate enantiomeric excess.