1,1'-binaphthalene-8,8'-diol as en efficient chiral controller: Highly enantioselective synthesis of optically active ketones

Article abstract of DOI:10.1016/0040-4039(96)01659-0

Half esters (R)-5 of 1,1'-binaphthalene-8,8'-diol undergo 1,4-addition of lithium dialkyl cuprates followed by formal 1,2-addition to give β-substituted ketones (S)-6 or (S)-7 with high enantioselectivity (96 ~ 100% ee). A brief discussion of the mechanis