Journal of Organic Chemistry p. 3688 - 3699 (2016)
Update date:2022-08-11
Topics:
Li, Xiangdong
Xie, Xin
Liu, Yuanhong
An efficient and atom-economic method for the synthesis of multisubstituted indolizines via gold-catalyzed cascade hydroarylation/cycloaromatization reaction of α-(N-pyrrolyl)ketones with alkynes is described. The reaction is realized through the construction of the pyridine ring of indolizines, which allows the regioselective incorporation of a wide range of functionalities on the pyridine unit.
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