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1
form to expand the repertoire of caged compounds, allowing 16 T. Furuta, K. Manabe, A. Teraoka, K. Murakoshi, A. Ohtsubo and
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This method was applied to the preparation of novel water-
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0–12,24,25,28
amine, previously reported Bhc caged compounds
can now be modified with a wide range of groups using the
2
9
strategy presented here to make their caging group ‘‘clickable’’.
4492–4496.
This work was supported by JSPS KAKENHI Grant Number 22 M. Noguchi, M. Skwarczynski, H. Prakash, S. Hirota, T. Kimura,
Y. Hayashi and Y. Kiso, Bioorg. Med. Chem., 2008, 16, 5389–5397.
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24 T. Furuta, K. Nishiyama, A. Manabe, M. Fukuoka and M. Iwamura,
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JP16H06280 (TF), Grant-in-Aid for Scientific Research on Innova-
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Resources ‘‘Advanced Bioimaging Support’’.
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5 T. Furuta, H. Takeuchi, M. Isozaki, Y. Takahashi, M. Kanehara,
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Conflicts of interest
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There are no conflicts of interests to declare.
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Notes and references
28 For example, D. Abate-Pella, N. A. Zeliadt, J. D. Ochocki, J. K.
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29 Very recently a similar concept ‘‘click’’ cage was reported. N. Wagner,
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G. Bort, T. Gallavardin, D. Ogden and P. I. Dalko, Angew. Chem.,
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54 | Chem. Commun., 2019, 55, 451--454
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