An improved reduction procedure in the synthesis of substituted pyrrolidines via an aminomercuration/reduction sequence of primary alkenylamines

Article abstract of DOI:10.1080/00397919608003517

Aminomercuration/reduction sequence of δ-alkenylamines is a typical route to substituted pyrrolidines. Backward reaction to the starting material is a major drawback which occurs during sodium borohydride reduction of the intermediate organomercurial. We describe here a new reduction procedure which prevents almost completely this backward reaction and leads to significant increases in the yields of pyrrolidines.

Full text of DOI:10.1080/00397919608003517

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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An Improved Reduction
Procedure in the Synthesis
of Substituted Pyrrolidines
via An Aminomercuration/
Reduction Sequence of Primary
Alkenylamines
a
a
Valérie Roubaud , François Le Moigne , Anne
a
a
Mercier & Paul Tordo
a
Laboratoire Structure et Réactivité des Espèces
Paramagnétiques, Case 521, Unité de Recherche
Associée N°1412 du, Centre National de la
Recherche Scientifique, Université de Provence,
Centre de St Jérome, 13397, Marseille Cedex 20,
France
Version of record first published: 15 Aug 2006.
To cite this article: Valérie Roubaud , François Le Moigne , Anne Mercier & Paul Tordo
(1996): An Improved Reduction Procedure in the Synthesis of Substituted Pyrrolidines
via An Aminomercuration/Reduction Sequence of Primary Alkenylamines, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 26:8, 1507-1516
To link to this article: http://dx.doi.org/10.1080/00397919608003517
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