A chemoenzymatic synthesis of 9(11)-secosteroids using an enzyme extract of the marine gorgonian Pseudopterogorgia americana

Article abstract of DOI:10.1016/0040-4039(96)01942-9

A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana has been developed which efficiently transforms a variety of sterols to their 9(11)-secosteroid derivative in high yield. NAD, NADP and glutamate dehydrogenase are key additives in this enzymatic conversion. In addition to naturally occurring metabolites, novel secosteroids have been prepared.