A chemoenzymatic synthesis of 9(11)-secosteroids using an enzyme extract of the marine gorgonian Pseudopterogorgia americana

DOI: 10.1016/0040-4039(96)01942-9

Source and publish data:

Tetrahedron Letters p. 8301 - 8304 (1996)

Update date:2022-08-16

Topics:

Authors:

Kerr, Russell G.

Rodriguez, Lesbeth C.

Kellman, Jaelle

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Article abstract of DOI:10.1016/0040-4039(96)01942-9

A fortified enzyme preparation of the gorgonian Pseudopterogorgia americana has been developed which efficiently transforms a variety of sterols to their 9(11)-secosteroid derivative in high yield. NAD, NADP and glutamate dehydrogenase are key additives in this enzymatic conversion. In addition to naturally occurring metabolites, novel secosteroids have been prepared.

Full text of DOI:10.1016/0040-4039(96)01942-9

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