Synthesis of (±)-15-thia-15-deoxy-PGE1 methyl ester

Article abstract of DOI:10.1139/v94-001

The 15-thia-15-deoxy analogue of prostaglandin E₁ methyl ester has been prepared by the zirconocene chloride mediated conjugate addition of an n-pentyl ethynyl sulfide derived anion to an appropriately substituted cyclopentenone. Similar methodology has also been used to prepare other 3-(3'-thia-1'-octenyl)-cyclopentanones.