Preparation of high specific activity tritium labeled 6α,9,-difluoro- 11 β,21-dihydroxy- 16α,17-[(1-methylethylidene)bis(oxy)]pregna- 1,4-diene-3,20-one, fluocinolone acetonide

Article abstract of DOI:10.1002/jlcr.1575

Fluocinolone acetonide was tritiated by selective reduction of the 1,2-double bond of the O-protected analog under tritium, followed by re-establishment of the 1,2-double bond and deprotection. Protection of both hydroxyl functionalities was required. The product was obtained with specific activity 36.8Ci/mmol. Copyright