A comparative kinetic study of nucleophilic substitution under PTC conditions in liquid-liquid and solid-liquid systems

Article abstract of DOI:10.1016/S0040-4020(99)00208-2

The phenomenon of initial exponential burst (IB) on kinetic curves in the reaction with solid salts was observed in the study on the S(N)2 substitution reaction of 2-octylmesylate with potassium halides under phase- transfer catalysis (PTC) conditions in liquid-liquid (l/l) and solid-liquid (s/l) systems. The mechanistic scheme describing the IB phenomenon in application to s/l PTC has been developed from the analysis of IB kinetic model known in enzyme kinetics.