Organic Letters p. 6380 - 6383 (2016)
Update date:2022-08-11
Topics:
Haas, Diana
Sustac-Roman, Daniela
Schwarz, Sophia
Knochel, Paul
The directed zincation of tropolone derivatives was achieved using TMPZnCl·LiCl. Various functionalizations of the zincated intermediates by halogenation, acylation, allylation, and Negishi cross-coupling were successfully performed. Additionally, 1,8-conjugate addition-elimination reactions with a variety of arylmagnesium and secondary alkylzinc reagents were carried out to further elaborate the tropolone core.
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