New Journal of Chemistry p. 9984 - 9989 (2017)
Update date:2022-08-16
Topics:
Weck, Christian
Obst, Franziska
Nauha, Elisa
Schofield, Christopher J.
Gruber, Tobias
The synthesis of the 6-azabicyclo[3.2.1]octane ring system, via Dieckmann cyclization, is described. Ring closure involves reaction of a caprolactam enolate with a C-6 ester, the reactive axial conformation of which is promoted by the presence of an N-tert-butyloxycarbonyl group on the lactam nitrogen. The results will enable the synthesis of new bridged caprolactams for testing as antibacterials and nucleophilic enzyme inhibitors.
Contact:86 311 85902108 / 85902109
Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Contact:86 311 85902108 / 85902109
Address:room 1001-1005 ,huanghe Road ,shijiazhuang ,China
Taizhou Chemedir Biopharm-tech Co., Ltd
Contact:+86 523 86200218
Address:G09, No. 1 Avenue China Medical City, Taizhou,Jiangsu, China
FOSHAN NANHAI ZHONGNAN PHARMACEUTICAL FACTORY
Contact:0086-0757-85609331
Address:XIAHENGTIAN INDUSTRIAL ZONE,SHAYONG VILLAGE,LISHUI TOWN
website:https://www.bocsci.com/
Contact:1-631-485-4226
Address:Ramsey Road
Doi:10.1016/S0031-9422(00)90582-X
(1994)Doi:10.1016/j.jcat.2007.10.003
(2007)Doi:10.1039/c4nj00900b
(2014)Doi:10.1016/j.tetlet.2003.10.154
(2004)Doi:10.1021/jp049482h
(2004)Doi:10.1021/jo00361a017
(1986)
