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D. Vourloumis et al. / Tetrahedron Letters 44 (2003) 2807–2811
In conclusion, we have described the synthesis of two
libraries containing molecules biased for RNA-binding,
1(x,y) and 2-Ar(x,y,z) or 2-R2(x,y,w), based on the
privileged benzimidazole scaffold. Careful design
allowed the introduction of a variety of polar groups on
the periphery of the molecules. Library synthesis was
realized with the use of SPOS in high average yields
and purity. Intermediates and final products were mon-
itored and quantitated by NMR spectroscopy utilizing
DMFu as an internal standard. Biological screening
against a variety of different bacterial and viral RNA-
targets is currently under investigation.
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Acknowledgements
We thank Dr. Charles G. Shevlin for analytical work
and Aileen Calimlim for her assistance in the prepara-
tion of this manuscript.
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